TRIM5 SUPPRESSES CROSS-SPECIES TRANSMISSION OF A PRIMATE IMMUNODEFICIENCY VIRUS AND SELECTS FOR EMERGENCE OF RESISTANT VARIANTS IN THE NEW SPECIES.

TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.

Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in WOMENS SKIRTS rhesus macaques, and SIVstm in stump-tailed macaques.Cellular assays and phylogenetic comparisons indirectly support a role for TRIM5alpha, the product of the TR

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A Cardiovascular Disease Prediction Model Based on Routine Physical Examination Indicators Using Machine Learning Methods: A Cohort Study

BackgroundCardiovascular diseases (CVD) are currently the leading cause of premature death worldwide.Model-based early detection of high-risk populations for CVD is the key to CVD prevention.Thus, this research aimed to use machine learning (ML) algorithms to establish a CVD prediction model based on routine physical examination indicators suitable

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